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Aplastic anaemia & marrow failure

Anaemia aplastica · Aplastická anémie a selhání kostní dřeně

What it is

The marrow stops producing all three cell lines.

Symptoms & signs

  • Fatigue and pallor
  • bleeding and bruising
  • repeated severe infections
  • breathlessness

🚩 Get help if…

  • call 112 / 911 now Fever over 38 °C
  • call 112 / 911 now Bleeding that will not stop
  • see a doctor soon Bruises or tiny red spots appearing without reason
  • see a doctor soon Growing paleness and breathlessness

Where it strikes

Medical treatment

  • Immunosuppression (ATG + ciclosporin)
  • eltrombopag
  • stem-cell transplant in the young
  • transfusion support
  • G-CSF

Natural & lifestyle

  • Infection precautions
  • avoid NSAIDs and alcohol
  • dental hygiene
  • nutritional support

Emerging & experimental

  • Haploidentical transplant protocols
  • gene-corrected autologous stem cells

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Traditional Chinese kidney-tonifying herbs — Chinese trials alongside immunosuppression early / small studies
  • 'Immune boosters' — the problem is an immune attack; boosting it is the wrong direction anecdotal / traditional

ICD codes