Anatom3D
ENCZDE
Download

Essential thrombocythaemia

Thrombocythaemia essentialis · Esenciální trombocytémie

What it is

A marrow disorder (JAK2, CALR or MPL mutation) that makes too many platelets, raising the risk of clots and, oddly, bleeding.

Symptoms & signs

  • Often none, found on a blood count
  • headaches, dizziness, visual flashes
  • burning red hands and feet
  • clots in legs, brain or heart
  • bleeding with very high counts

🚩 Get help if…

  • call 112 / 911 now Sudden weakness of face or limbs, or slurred speech
  • call 112 / 911 now Chest pain or sudden breathlessness
  • see a doctor soon One leg swollen, painful and warm
  • see a doctor soon Burning, red fingers or toes or unusual bleeding

Where it strikes

Medical treatment

  • Genetic testing and marrow biopsy
  • low-dose aspirin
  • hydroxycarbamide for high risk
  • anagrelide or interferon
  • control of cardiovascular risk

Natural & lifestyle

  • No smoking
  • exercise and hydration
  • blood-pressure and cholesterol control

Emerging & experimental

  • Bomedemstat
  • ropeginterferon

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Curcumin — lab studies on JAK2-mutant cells early / small studies
  • Nattokinase and fish oil — anecdotal; add bleeding risk with aspirin anecdotal / traditional
  • Exercise — lowers clot risk generally early / small studies

ICD codes