Anatom3D
ENCZDE
Download

Mast cell activation & mastocytosis

Mastocytosis et syndroma activationis mastocytorum · Aktivace žírných buněk a mastocytóza

What it is

Too many or too twitchy mast cells release mediators unpredictably.

Symptoms & signs

  • Flushing
  • hives
  • abdominal cramps
  • diarrhoea
  • palpitations
  • anaphylaxis without a clear trigger
  • bone pain

🚩 Get help if…

  • call 112 / 911 now Swelling of lips or throat, wheeze or trouble breathing
  • call 112 / 911 now Fainting or feeling faint with flushing
  • see a doctor soon Bone pain or a broken bone after little force
  • see a doctor soon Weight loss, big liver or spleen or swollen nodes

Where it strikes

Medical treatment

  • H1 and H2 antihistamines
  • cromolyn sodium
  • midostaurin or avapritinib for systemic disease
  • adrenaline auto-injector

Natural & lifestyle

  • Trigger avoidance (heat, alcohol, NSAIDs, stress)
  • low-histamine diet trial
  • written emergency plan

Emerging & experimental

  • KIT D816V inhibitors (bezuclastinib)
  • anti-Siglec-8 (lirentelimab)

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Quercetin and luteolin — laboratory mast-cell stabilisers; small studies early / small studies
  • DAO enzyme supplements — patients report fewer food reactions; untested anecdotal / traditional

ICD codes