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MGUS (monoclonal gammopathy)

Gammopathia monoclonalis incerti significationis · MGUS (monoklonální gamapatie)

What it is

One clone of plasma cells makes a single antibody in excess, harmlessly — in 3% of people over 50 — but 1% a year progress to myeloma or related disease.

Symptoms & signs

  • No symptoms
  • found by chance on a protein test
  • occasionally nerve damage (numb feet)
  • kidney damage in a few

🚩 Get help if…

  • call 112 / 911 now New back pain with leg weakness or loss of bladder control
  • see a doctor soon New bone pain or a broken bone after little force
  • see a doctor soon Great thirst, confusion or constipation
  • see a doctor soon Infections that keep coming back, or weight loss

Where it strikes

Medical treatment

  • Serum protein electrophoresis and free light chains
  • risk stratification
  • yearly monitoring
  • investigate any anaemia, bone pain, kidney change

Natural & lifestyle

  • Healthy weight
  • no smoking

Emerging & experimental

  • Early treatment of high-risk smouldering disease
  • screening trials (iStopMM)

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Curcumin — small studies lowered the paraprotein early / small studies
  • Vitamin D — low levels common; untested for progression early / small studies
  • Green tea — anecdotal anecdotal / traditional

ICD codes