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Pancreatic cancer

Carcinoma pancreatis · Rakovina slinivky

What it is

Silent until late; one of the hardest cancers to treat.

Symptoms & signs

  • Painless jaundice
  • weight loss
  • back pain
  • new diabetes over 50
  • pale stools
  • itching

🚩 Get help if…

  • call 112 / 911 now Sudden breathlessness or chest pain (clot in the lung)
  • see a doctor soon Yellow skin or eyes, often with itching
  • see a doctor soon Weight loss with upper belly or back pain
  • see a doctor soon New diabetes after 50 with weight loss

Where it strikes

Medical treatment

  • Whipple resection if operable
  • FOLFIRINOX or gemcitabine-nab-paclitaxel
  • biliary stenting
  • enzyme replacement
  • pain control with coeliac plexus block

Natural & lifestyle

  • Nutritional support with enzymes
  • exercise as tolerated
  • smoking cessation
  • palliative care early (better quality of life)

Emerging & experimental

  • KRAS G12D inhibitors
  • mRNA neoantigen vaccines (autogene cevumeran)
  • CAR-T and stroma-targeting agents

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Gonzalez pancreatic-enzyme regimen — a controlled study found survival three times shorter than with chemotherapy not confirmed in trials
  • Intravenous vitamin C with chemotherapy — a small trial (Iowa, 2024) doubled survival in metastatic disease early / small studies
  • Ketogenic diet — early studies early / small studies
  • Ivermectin and fenbendazole — anecdotal; no human trials anecdotal / traditional

ICD codes