Anatom3DPeyronie's disease
Induratio penis plastica · Peyronieho choroba
male only
What it is
Scar plaque in the sheath of the erectile tissue bends the erect penis; it often follows small injuries during sex.
Symptoms & signs
- Curved or indented erection
- a hard lump on the shaft
- pain on erection early on
- shortening
- erectile dysfunction
🚩 Get help if…
- call 112 / 911 now Sudden crack, pain and swelling of the penis during sex
- call 112 / 911 now An erection that lasts more than 4 hours
- see a doctor soon A bend that makes sex impossible or painful
- see a doctor soon A hard lump that grows fast or is very painful
Where it strikes
Medical treatment
- Wait 12 months for it to stabilise
- traction therapy
- collagenase injections (Xiaflex)
- plication or grafting surgery
- penile implant with severe erectile dysfunction
Natural & lifestyle
- Stop smoking
- treat diabetes
- avoid bending injuries during sex
Emerging & experimental
- Shockwave therapy for pain
- verapamil or interferon injections
- platelet-rich plasma
Alternative, off-label & anecdotal
Approaches used outside the guidelines, with what their supporters report and what testing has found so far.
- Vitamin E — widely used; trials found no benefit not confirmed in trials
- Pentoxifylline — small trials may slow plaque growth mixed evidence
- L-arginine and tadalafil with traction — small trials early / small studies
- Potassium aminobenzoate (Potaba) — slowed plaque growth in a trial, did not straighten the curve mixed evidence
ICD codes
- ICD-10 N48.6
- ICD-11 GB06.2 Penile fibromatosis