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Clotting disorders (thrombophilia & APS)

Thrombophilia et syndroma antiphospholipidicum · Poruchy srážlivosti (trombofilie a APS)

What it is

The blood clots too easily — inherited (factor V Leiden) or autoimmune (antiphospholipid).

Symptoms & signs

  • Unprovoked DVT or PE
  • recurrent miscarriage
  • stroke in the young
  • livedo rash in APS

🚩 Get help if…

  • call 112 / 911 now Sudden breathlessness, chest pain or coughing blood
  • call 112 / 911 now Sudden weakness of face or limbs, or slurred speech
  • see a doctor soon One leg swollen, painful and warm
  • see a doctor soon Repeated miscarriages

Where it strikes

Medical treatment

  • Anticoagulation (warfarin preferred in APS)
  • hydroxychloroquine in APS
  • thromboprophylaxis in pregnancy and surgery

Natural & lifestyle

  • Mobility on long journeys
  • avoid oestrogen-containing contraception
  • hydration
  • compression

Emerging & experimental

  • Factor XI inhibitors
  • complement-targeted therapy in catastrophic APS

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Nattokinase — sold as a natural blood thinner; unproven, with bleeding risk alongside anticoagulants anecdotal / traditional
  • Swings in vitamin K intake on warfarin — keep it steady rather than avoid it anecdotal / traditional

ICD codes