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Bile duct cancer (cholangiocarcinoma)

Cholangiocarcinoma · Nádor žlučových cest (cholangiokarcinom)

What it is

Cancer of the bile ducts, often found late when jaundice appears; linked to primary sclerosing cholangitis and liver flukes.

Symptoms & signs

  • Painless jaundice
  • itching
  • pale stools, dark urine
  • weight loss
  • abdominal pain

🚩 Get help if…

  • call 112 / 911 now Fever with shivers and yellow skin
  • see a doctor soon Yellow skin or eyes with dark urine and pale stools
  • see a doctor soon Itching all over with yellowing
  • see a doctor soon Weight loss with pain under the right ribs

Where it strikes

Medical treatment

  • CT, MRI and ERCP with brushings
  • surgery if removable
  • stents for jaundice
  • gemcitabine–cisplatin with durvalumab
  • FGFR2 or IDH1 inhibitors when mutated

Natural & lifestyle

  • Treat PSC; no raw freshwater fish (liver flukes)
  • no alcohol

Emerging & experimental

  • Liver transplant for selected cases
  • photodynamic therapy

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Curcumin — lab studies early / small studies
  • Milk thistle — anecdotal anecdotal / traditional
  • Metformin — observational links to lower risk early / small studies

ICD codes