Anatom3DDiabetes insipidus (arginine vasopressin deficiency)
Diabetes insipidus · Diabetes insipidus (nedostatek argininvazopresinu)
What it is
Without ADH the kidneys leak litres of dilute urine.
Symptoms & signs
- Passing 3–20 L of urine a day
- unquenchable thirst
- nocturia
- dehydration
🚩 Get help if…
- call 112 / 911 now Confusion, fits or extreme drowsiness
- call 112 / 911 now Can't drink enough to keep up, with dizziness or fainting
- see a doctor soon Headache, nausea or confusion after desmopressin and drinking a lot
- see a doctor soon Sudden thirst and huge amounts of urine after head injury or surgery
Where it strikes
Medical treatment
- Desmopressin for central type
- thiazides and amiloride for nephrogenic type
- treat the underlying cause
Natural & lifestyle
- Free access to water at all times
- electrolyte monitoring
- medical alert identification
Emerging & experimental
- Long-acting vasopressin analogues
- copeptin-based diagnosis
Alternative, off-label & anecdotal
Approaches used outside the guidelines, with what their supporters report and what testing has found so far.
- Low-salt, low-protein diet in the kidney type — lowers urine volume and is used in clinics mixed evidence
- Avoiding caffeine and liquorice — common sense; untested anecdotal / traditional
ICD codes
- ICD-10 E23.2
- ICD-11 5A61.5 Central diabetes insipidus