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Systemic lupus erythematosus

Lupus erythematosus systemicus · Systémový lupus erythematodes

What it is

Antibodies against the body's own nuclei; almost any organ can be hit.

Symptoms & signs

  • Butterfly facial rash
  • joint pain
  • extreme fatigue
  • photosensitivity
  • mouth ulcers
  • kidney involvement
  • hair loss
  • fever

🚩 Get help if…

  • call 112 / 911 now Chest pain or sudden shortness of breath
  • call 112 / 911 now Seizure, confusion or sudden weakness on one side
  • see a doctor soon Foamy urine, swollen legs or much less urine
  • see a doctor soon Fever over 38 °C on immune-suppressing drugs

Where it strikes

Medical treatment

  • Hydroxychloroquine for everyone
  • steroids for flares
  • mycophenolate or cyclophosphamide for nephritis
  • belimumab
  • anifrolumab

Natural & lifestyle

  • Sun protection factor 50 daily
  • vitamin D
  • smoking cessation
  • paced exercise
  • infection prevention
  • stress management

Emerging & experimental

  • CAR-T therapy (drug-free remissions in small case series)
  • obinutuzumab
  • interferon-targeted therapy

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • DHEA — trials show modest benefit and some steroid-sparing mixed evidence
  • Omega-3 — small trials reduce activity early / small studies
  • Turmeric — small trials in lupus nephritis early / small studies
  • Echinacea and alfalfa — can stir up lupus; avoid anecdotal / traditional

ICD codes