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Myelofibrosis

Myelofibrosis primaria · Myelofibróza

What it is

A marrow cancer that scars the marrow, so blood is made in the spleen and liver instead — a huge spleen, anaemia and exhaustion.

Symptoms & signs

  • Tiredness and anaemia
  • very enlarged spleen, early fullness
  • night sweats and weight loss
  • bone pain
  • itching

🚩 Get help if…

  • call 112 / 911 now Sudden severe pain under the left ribs
  • call 112 / 911 now Vomiting blood or black stools
  • see a doctor soon Fever or infections that keep coming back
  • see a doctor soon Bleeding or bruising easily, or getting more breathless

Where it strikes

Medical treatment

  • Blood count, marrow biopsy and genetic tests
  • ruxolitinib or fedratinib
  • momelotinib or pacritinib
  • transfusions
  • stem-cell transplant for fit patients

Natural & lifestyle

  • Small frequent meals while the spleen is big
  • exercise within limits

Emerging & experimental

  • Navitoclax, pelabresib
  • telomerase inhibitors (imetelstat)

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Curcumin — lab studies on JAK2 early / small studies
  • Herbal blood builders — anecdotal anecdotal / traditional
  • Omega-3 — anti-inflammatory; untested here early / small studies

ICD codes