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SIADH (inappropriate antidiuretic hormone)

Syndroma secretionis inadaequatae hormoni antidiuretici · SIADH (nepřiměřená sekrece antidiuretického hormonu)

What it is

Too much water-retaining hormone leaves the blood too dilute (low sodium) — from lung disease, brain disorders, cancers or drugs.

Symptoms & signs

  • Often nothing if mild
  • nausea and headache
  • confusion
  • falls
  • seizures when severe

🚩 Get help if…

  • call 112 / 911 now Fits, confusion or drowsiness
  • call 112 / 911 now Vomiting with a severe headache
  • see a doctor soon New unsteadiness, falls or muddled thinking
  • see a doctor soon Nausea and tiredness after starting a new medicine

Where it strikes

Medical treatment

  • Blood and urine sodium and osmolality
  • fluid restriction
  • treat the cause, stop culprit drugs
  • tolvaptan or urea
  • hypertonic saline for severe symptoms, slowly

Natural & lifestyle

  • Drink to thirst, not beyond
  • care with sports drinks and water loading

Emerging & experimental

  • SGLT2 inhibitors
  • oral urea formulations

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Drinking more water — makes it worse not confirmed in trials
  • Salt tablets alone — help only with fluid restriction anecdotal / traditional
  • Herbal diuretics — lose salt as well as water anecdotal / traditional

ICD codes