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Peptic ulcer disease

Ulcus pepticum · Vředová choroba žaludku a dvanáctníku

What it is

Acid eats through the lining, nearly always because of H. pylori or NSAIDs.

Symptoms & signs

  • Gnawing upper-abdominal pain
  • better or worse with food
  • nausea
  • black tarry stools if bleeding

🚩 Get help if…

  • call 112 / 911 now Vomiting blood or coffee-ground material
  • call 112 / 911 now Black tarry stools or fainting
  • call 112 / 911 now Sudden severe belly pain with a rigid belly
  • see a doctor soon Repeated vomiting, weight loss or food sticking

Where it strikes

Medical treatment

  • H. pylori eradication (triple/quadruple therapy)
  • PPI
  • stop NSAIDs
  • endoscopic clipping for bleeding
  • Vonoprazan-based H. pylori eradication (Voquezna packs) — FDA-approved 2022

Natural & lifestyle

  • Avoid NSAIDs, alcohol and smoking
  • mastic gum and broccoli sprouts (sulforaphane) have small anti-H. pylori evidence
  • regular meals

Emerging & experimental

  • H. pylori vaccine research

Alternative, off-label & anecdotal

Approaches used outside the guidelines, with what their supporters report and what testing has found so far.

  • Probiotics (Lactobacillus reuteri, Saccharomyces boulardii) with eradication therapy — meta-analyses show more cures and fewer side effects trials support
  • Mastic gum — clears H. pylori in a minority in small trials mixed evidence
  • Broccoli sprouts (sulforaphane) — small trials lower the H. pylori load early / small studies
  • Raw cabbage juice — 1950s reports of fast ulcer healing; never retested anecdotal / traditional
  • Manuka honey — kills H. pylori in the laboratory; small human studies disappointing early / small studies

ICD codes