Anatom3DSubstantia nigra
Substantia nigra · Černá substance
Nervous system
Looks like
A dark band of pigmented grey matter in the midbrain on each side.
What it does
Makes dopamine for the basal ganglia so movement runs smoothly.
Keeping it well
Its cells die in Parkinson's disease; a one-sided tremor at rest, slowness and stiffness need a neurologist.
Related conditions
- Acute liver failure
- ADHD
- African trypanosomiasis (sleeping sickness)
- Alcohol withdrawal and delirium tremens
- Altitude sickness
- Alzheimer's disease
- Amyloidosis (AL and ATTR)
- Autism spectrum disorder
- Bipolar disorder
- Birth asphyxia (hypoxic-ischaemic encephalopathy)
- Body dysmorphic disorder
- Botulism
- Brain abscess
- Brain aneurysm
- Brain tumour (glioma & meningioma)
- Cerebral palsy
- Chiari malformation and syringomyelia
- Chickenpox (varicella)
- Chronic insomnia
- Chronic neuropathic pain
- Chronic pain syndrome
- Cluster headache
- Concussion (mild TBI)
- Congenital hypothyroidism
- Cryptococcal meningitis
- Delirium
- Dementia with Lewy bodies
- Down syndrome (trisomy 21)
- Drowning
- Eating disorders
- Encephalitis
- Epilepsy
- Essential tremor & dystonia
- Fainting (syncope)
- Febrile seizures
- Fibromyalgia
- Fragile X syndrome
- Frailty & falls in older age
- Functional (somatic) symptom disorder
- Generalised anxiety disorder
- Guillain-Barré syndrome
- Haemorrhagic stroke
- Heat exhaustion & heatstroke
- Hepatic encephalopathy
- Huntington's disease
- Hydrocephalus
- Hypoglycaemia (low blood sugar)
- Intellectual disability
- Ischaemic stroke
- Japanese encephalitis
- Lead poisoning
- Long COVID (post-viral syndrome)
- Lyme disease
- Major depressive disorder
- ME/chronic fatigue syndrome
- Measles
- Medication-overuse headache
- Meningitis
- Migraine
- Multiple sclerosis
- Myasthenia gravis
- Narcolepsy
- Neurocysticercosis
- Normal pressure hydrocephalus
- Parkinson's disease
- Peripheral neuropathy
- Phenylketonuria (PKU)
- Poisoning & overdose
- Post-traumatic stress disorder
- Postnatal depression
- Postpartum psychosis
- Rabies
- Restless legs syndrome
- Roseola (sixth disease)
- Schizophrenia
- Self-harm and suicidal crisis
- Shingles (herpes zoster)
- Subdural haematoma
- Substance use disorder
- Sudden infant death syndrome
- Tension-type headache
- Tetanus
- Thrombotic thrombocytopenic purpura (TTP)
- Tick-borne encephalitis
- Tics and Tourette syndrome
- Toxoplasmosis & CMV
- Transient ischaemic attack
- Traumatic brain injury (moderate to severe)
- Trigeminal neuralgia
- Tuberous sclerosis complex
- Vascular dementia
- Vestibular schwannoma (acoustic neuroma)
- Vitamin B1, C and other deficiencies